https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53952 Wed 28 Feb 2024 15:24:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45703 Wed 24 Jan 2024 14:33:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29578 Wed 17 Nov 2021 16:29:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25641 Wed 11 Apr 2018 15:12:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20009 Wed 11 Apr 2018 09:19:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36835 Wed 08 Jul 2020 16:08:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53160 Wed 06 Mar 2024 14:25:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13845 Tue 24 Aug 2021 14:32:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:499 Thu 25 Jul 2013 09:10:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:602 Thu 25 Jul 2013 09:10:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:444 Thu 25 Jul 2013 09:09:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:165 Thu 25 Jul 2013 09:09:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55126 Thu 11 Apr 2024 11:13:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36097 Helicobacter pylori and other pathophysiological changes, most notably duodenal pathology, namely duodenal eosinophilia, permeability alterations, structural neuronal changes and microbial duodenal dysbiosis. This has led to the idea that FD is a true disease entity and triggers of this condition based on epidemiology studies point towards allergy, immune disorders and infection. Anxiety and depression may precede or follow FD, (brain-gut/gut-brain disorders). Currently most therapies for FD are inadequate but underlying pathology may lead to targeted treatment success as an attainable goal.]]> Thu 06 Feb 2020 09:59:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8598 Sat 24 Mar 2018 08:38:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9527 Sat 24 Mar 2018 08:35:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1218 Sat 24 Mar 2018 08:28:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1376 Sat 24 Mar 2018 08:28:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14610 Sat 24 Mar 2018 08:20:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13297 Sat 24 Mar 2018 08:18:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12415 + lymphocytes (Th2 cells) and their cytokines predominate in mild to moderate allergic asthma, whereas severe steroid-resistant asthma has more of a mixed Th2/Th1 phenotype with a Th17 component. Other immune cells, particularly neutrophils, macrophages and dendritic cells, as well structural cells such as epithelial and airway smooth muscle cells also produce disease-associated cytokines in asthma. Increased levels of these immune cells and cytokines have been identified in clinical samples and their potential role in disease demonstrated in studies using mouse models of asthma. Clinical trials with inhibitors of cytokines such as interleukin (IL)-4, -5 and tumour necrosis factor-α have had success in some studies but not others. This may reflect the design of the clinical trials, including treatments regimes and the patient population included in these studies. IL-13, -9 and granulocyte-macrophage colony-stimulating factor are currently being evaluated in clinical trials or preclinically and the outcome of these studies is eagerly awaited. Roles for IL-25, -33, thymic stromal lymphopoietin, interferon-γ, IL-17 and -27 in the regulation of asthma are just emerging, identifying new ways to treat inflammation. Careful interpretation of results from mouse studies will inform the development and application of therapeutic approaches for asthma. The most effective approaches may be combination therapies that suppress multiple cytokines and a range of redundant and disconnected pathways that separately contribute to asthma pathogenesis. Astute application of these approaches may eventually lead to the development of effective asthma therapeutics. Here we review the current state of knowledge in the field.]]> Sat 24 Mar 2018 08:14:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11170 Sat 24 Mar 2018 08:10:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16796 Sat 24 Mar 2018 08:00:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19810 Sat 24 Mar 2018 07:57:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21853 Sat 24 Mar 2018 07:55:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19973 Sat 24 Mar 2018 07:54:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20648 Sat 24 Mar 2018 07:53:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21468 N = 104) were randomly assigned to the experimental or control group. The experimental group received 12 sessions of group music therapy (two 30-min sessions per week for 6 weeks), and the control group received usual care. Data were collected 4 times: (1) 1 week before the intervention. ; (2) the 6th session of the intervention. ; (3) the 12th session of the intervention. ; (4) 1 month after the final session. Results: Group music therapy reduced depression in persons with dementia. Improvements in depression occurred immediately after music therapy and were apparent throughout the course of therapy. The cortisol level did not significantly decrease after the group music therapy. Cognitive function significantly improved slightly at the 6th session, the 12th session, and 1 month after the sessions ended; in particular, short-term recall function improved. The group music therapy intervention had the greatest impact in subjects with mild and moderate dementia. Conclusion: The group music intervention is a noninvasive and inexpensive therapy that appeared to reduce elders’ depression. It also delayed the deterioration of cognitive functions, particularly short-term recall function. Group music therapy may be an appropriate intervention among elderly persons with mild and moderate dementia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5817 Sat 24 Mar 2018 07:48:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5773 Sat 24 Mar 2018 07:47:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5035 Sat 24 Mar 2018 07:45:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:138 Sat 24 Mar 2018 07:43:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:372 Sat 24 Mar 2018 07:42:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28656 n = 100) for five-months following hospital discharge after stroke (plus usual care) and compared with usual care (n = 101). Ethical approval was obtained to withhold information about the intervention and primary outcome from participants during the consent process. Results: No significant difference was seen in the proportion of participants with depression in the intervention group (1/88) vs. the control group (3/76) (relative risk 0·29, 95% confidence interval 0·03–2·71) at six-months. No significant differences were seen on Hospital Anxiety Depression Scale (HADS) depression and anxiety sub-scale scores, quality of life, or activities of daily living; however, many (47/100) responded positively to the postcards. Conclusions: Although this simple postcard intervention did not significantly reduce the proportion of participants experiencing high HADS depression sub-scale scores after stroke, it may be an effective way to engage with people after stroke following hospital discharge.]]> Sat 24 Mar 2018 07:37:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31000 N = 3,276; Australia, Brazil, Canada, Hong Kong, Portugal, Romania, Taiwan, Turkey, United Arab Emirates, and United States). Using structural equation modeling, we found that self-stigma mediated the relationship between public stigma and attitudes toward seeking services among college students in each country and region. However, differences in path strengths emphasize the need to pay attention to the role of public and self-stigma on attitudes toward seeking psychological services throughout the world.]]> Sat 24 Mar 2018 07:27:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26933 Opioid Treatment Index social functioning scale. Those classified in the highest quartile (score >6) were considered having lower social functioning. Analyses were performed using logistic regression. Results: Among 415 participants (mean age 41 years, 71% male), 24% were considered having lower social functioning, 70% had early HCV treatment intent (intention to be treated in the next 12 months), 53% were assessed by a specialist and 27% initiated treatment. Lower social functioning was independently associated with unemployment, unstable housing, recent injecting drug use and moderate to extremely severe symptoms of depression, anxiety and stress. Lower social functioning was independently associated with reduced early HCV treatment intent (aOR 0.51, 95% CI 0.30-0.84) and lower specialist assessment (aOR 0.48, 95% CI 0.29-0.79), but not HCV treatment uptake (aOR 0.76, 95% CI 0.40-1.43). Living with someone was independently associated with HCV treatment uptake (with someone and children: aOR 2.28, 95% CI 1.01-5.14; with someone and no children: aOR 2.36, 95% CI 1.30-4.31), but not early HCV treatment intent or specialist assessment. Conclusions: This study highlights the need for the development and implementation of strategies targeting people who inject drugs with lower social functioning to enhance HCV treatment intent and specialist assessment. Further, strategies to enhance social support may play a role in increasing HCV treatment uptake.]]> Sat 24 Mar 2018 07:27:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23766 Sat 24 Mar 2018 07:11:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37732 p = 0.001), brainstem onset (HR = 0.45, p = 0.009), azathioprine (HR = 0.46, p <0.001) and mycophenolate mofetil (HR = 0.09, p = 0.012) were associated with a reduced risk of relapse. A greater EDSS was associated with age (β = 0.45 (per decade), p<0.001) and disease duration (β = 0.07 per year, p <0.001). A slower increase in EDSS was associated with azathioprine (β = -0.48, p <0.001), mycophenolate mofetil (β = -0.69, p = 0.04) and rituximab (β = -0.35, p = 0.024). Interpretation: This study has demonstrated that azathioprine and mycophenolate mofetil reduce the risk of relapses and disability progression is modified by azathioprine, mycophenolate mofetil and rituximab. Age and disease duration were the only patient characteristics that modified the risk of relapse and disability in our cohort.]]> Mon 29 Mar 2021 13:09:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47275 Mon 27 Mar 2023 13:35:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41847 p = 0.010); but no differences in spontaneous abortions, term or preterm births. Conclusions: We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.]]> Mon 15 Aug 2022 10:27:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48189 Mon 13 May 2024 12:49:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50818 Mon 07 Aug 2023 13:54:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22044 Chlamydia, Haemophilus influenzae and Streptococcus pneumoniae in early life may promote permanent deleterious changes in immunity, lung structure, and function that predispose to, or increase the severity of chronic respiratory diseases in later life. For example, these infections increase immune responses, which drive subsequent asthma pathogenesis. Targeting the pathways involved with specific inhibitors or agonists may prevent these consequences of early-life infection. Vaccination and immunomodulatory therapies that control the infections and their sequelae may also be efficacious.]]> Mon 01 Feb 2016 13:04:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50580 Fri 28 Jul 2023 14:29:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46553 Fri 25 Nov 2022 11:33:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41804 Fri 12 Aug 2022 12:31:50 AEST ]]>